Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester
CAS No.:583866-27-7
Molecular Formula:C₃₆H₅₀O₇S
Molecular Weight:626.855
Hs Code.:

Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Synonyms:Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Suppliers and Price of Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

There total 4 articles about Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 98-59-9
p-toluenesulfonyl chloride

: 583866-26-6
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butan-1-ol

: 583866-27-7
Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;
DOI:10.1021/jo0301301

Reference yield:

: 583866-64-2
(1S,2S,4S,8R)-2-[(1E,3S)-4-(p-methoxybenzyloxy)-3-methyl-1-butenyl]-8-[(1R)-1-[(tert-butyldimethylsiloxy)methyl]-2-methylpropyl]-1-methylbicyclo[2.2.2]oct-5-en-2-ol

: 583866-27-7
Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / 18-crown-6; potassium hexamethyldisilazide / tetrahydrofuran; toluene / 1 h / 120 °C / sealed tube

2: 84 percent / p-toluenesulfonic acid / benzene / 4 h / Heating

3: 100 percent / TBAF / tetrahydrofuran / 14 h / 20 °C

4: 91 percent / DMAP / CH₂Cl₂ / 20 °C

With dmap; 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; toluene; benzene;
DOI:10.1021/jo0301301

Reference yield:

: 583866-24-4
(4R,4aS,8R,8aR)-8-[(R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methyl-propyl]-4-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6-methyl-3,4,4a,7,8,8a-hexahydro-1H-naphthalen-2-one

: 583866-27-7
Toluene-4-sulfonic acid (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / p-toluenesulfonic acid / benzene / 4 h / Heating

2: 100 percent / TBAF / tetrahydrofuran / 14 h / 20 °C

3: 91 percent / DMAP / CH₂Cl₂ / 20 °C

With dmap; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo0301301