(S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Base Information

• Chemical Name: (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester
• CAS No.: 119673-72-2
• Molecular Formula: C₂₁H₂₇IO₃Si
• Molecular Weight: 482.434

Synonyms:(S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Chemical Property of (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

There total 4 articles about (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate (119673-71-1) → (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester (119673-72-2)

Guidance literature:

With sodium iodide; In butanone;

Reference yield:

(S)-bromo-3-hydroxybutyric acid methyl ester (88759-56-2) → (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester (119673-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole, DMAP / dimethylformamide / Ambient temperature

2: sodium iodide / butan-2-one / 5 h / Heating

With 1H-imidazole; dmap; sodium iodide; In N,N-dimethyl-formamide; butanone;

DOI:10.1021/jm00113a019

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester (119673-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole, DMAP / dimethylformamide / Ambient temperature

2: sodium iodide / butan-2-one / 5 h / Heating

With 1H-imidazole; dmap; sodium iodide; In N,N-dimethyl-formamide; butanone;

DOI:10.1021/jm00113a019

upstream raw materials:

Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate

(S)-bromo-3-hydroxybutyric acid methyl ester

tert-butylchlorodiphenylsilane

Downstream raw materials:

(S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

(S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

(S)-4-{[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester

(S)-4-{[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester

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