N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride

Base Information

• Chemical Name: N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride
• CAS No.: 467467-67-0
• Molecular Formula: C₈H₅ClF₃NO₂
• Molecular Weight: 239.581
• Mol file: 467467-67-0.mol

Synonyms:N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride

Chemical Property of N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride

There total 3 articles about N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride (467467-67-0)

Guidance literature:

Reference yield:

N-hydroxy-1-[4-(trifluoromethoxy)phenyl]methaneimine (150162-39-3) → N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride (467467-67-0)

Guidance literature:

With tert-butylhypochlorite; In methanol; at -5 - 0 ℃;

DOI:10.5012/bkcs.2014.35.4.1073

Reference yield:

p-trifluoromethoxybenzaldehyde (659-28-9) → N-hydroxy-4-(trifluoromethoxy)benzenecarboximidoyl chloride (467467-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / methanol / Reflux

2: tert-butylhypochlorite / methanol / -5 - 0 °C

With tert-butylhypochlorite; hydroxylamine hydrochloride; In methanol;

DOI:10.5012/bkcs.2014.35.4.1073

upstream raw materials:

p-trifluoromethoxybenzaldehyde

N-hydroxy-1-[4-(trifluoromethoxy)phenyl]methaneimine

Downstream raw materials:

(6S)-2-nitro-6-({3-[4-(trifluoromethoxy)phenyl]-5-isoxazolyl}methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine