sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid

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Chemical Name:sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid
CAS No.:77960-53-3
Molecular Formula:C₁₃H₁₀NO₃S*Na
Molecular Weight:283.283
Hs Code.:

Synonyms:sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid

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Chemical Property of sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid

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Technology Process of sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid

There total 5 articles about sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 77960-51-1
methyl 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylate

: 77960-53-3
sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; for 48h;
DOI:10.1248/cpb.28.3494

Reference yield:

: 77960-47-5
4-(3-methoxycarbonyl-2-oxopropyl)-2-azetidinone

: 77960-53-3
sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / Et₃N, p-toluenesulfonyl azide (TsN₃) / acetonitrile / Ambient temperature

2: 71 percent / rhodium (II) acetate 2(OCOCH₃)4> / 1,2-dimethoxy-ethane / Ambient temperature

3: 29 percent / tributylphosphine (Bu₃P) / dimethylformamide / 1.25 h / 40 - 50 °C

4: 67 percent / 0.1N aq. NaOH / H₂O; tetrahydrofuran / 48 h

With dirhodium tetraacetate; sodium hydroxide; 4-toluenesulfonyl azide; tributylphosphine; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.28.3494

Reference yield:

: 77960-49-7,127054-89-1,127054-90-4
4-(3-diazo-3-methoxycarbonyl-2-oxopropyl)-2-azetidinone

: 77960-53-3
sodium salt of 3-phenylthio-7-oxo-1-azabicyclo<3.2.0>hept-3-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / rhodium (II) acetate 2(OCOCH₃)4> / 1,2-dimethoxy-ethane / Ambient temperature

2: 29 percent / tributylphosphine (Bu₃P) / dimethylformamide / 1.25 h / 40 - 50 °C

3: 67 percent / 0.1N aq. NaOH / H₂O; tetrahydrofuran / 48 h

With dirhodium tetraacetate; sodium hydroxide; tributylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.28.3494