meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

Base Information

Chemical Name:meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester
CAS No.:370577-89-2
Molecular Formula:C₄₀H₄₂ClN₅O₈P₂
Molecular Weight:818.203
Hs Code.:

meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

Synonyms:meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

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Chemical Property of meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

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Technology Process of meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

There total 5 articles about meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 370577-87-0
meso-1,3-cis-[2-(2-chloro-6-methylaminopurin-9-ylmethyl)-3-hydroxymethylcyclopropyl]methanol

: 370577-89-2
meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

Guidance literature:: With lithium diethylamide; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h;
DOI:10.1021/jm010082h

Reference yield:

: 369627-28-1
[2,3-bis-(tert-butyldimethylsilanyloxymethyl)cyclopropyl]methanol

: 370577-89-2
meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

2: 31 mg / tetrahydrofuran / 5 h

3: aq. AcOH / tetrahydrofuran / 4 h / 20 °C

4: lithium diethylamide / tetrahydrofuran / 0.67 h / -78 - 20 °C

With lithium diethylamide; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: Mitsunobu reaction;
DOI:10.1021/jm010082h

Reference yield:

: 369627-27-0
2,3-bis-(tert-butyldimethylsilanyloxymethyl)cyclopropanecarboxylic acid ethyl ester

: 370577-89-2
meso-1,3-cis-phosphoric acid dibenzyl ester 2-(bis-benzyloxyphosphoyloxymethyl)-3-(2-chloro-6-methylaminopurin-9-ylmethyl)cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / litium borohydride / diethyl ether; toluene / 1 h / 100 °C

2: 59 percent / triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

3: 31 mg / tetrahydrofuran / 5 h

4: aq. AcOH / tetrahydrofuran / 4 h / 20 °C

5: lithium diethylamide / tetrahydrofuran / 0.67 h / -78 - 20 °C

With lithium borohydride; lithium diethylamide; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; toluene; 2: Mitsunobu reaction;
DOI:10.1021/jm010082h