(S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate

Base Information

Chemical Name:(S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate
CAS No.:1335387-04-6
Molecular Formula:C₃₀H₃₈N₄O₆S
Molecular Weight:582.721
Hs Code.:

Synonyms:(S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate

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Chemical Property of (S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate

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Technology Process of (S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate

There total 12 articles about (S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365171-49-8
C₃₀H₃₆N₄O₈S

: 1335387-04-6
(S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate

Guidance literature:: C₃₀H₃₆N₄O₈S; With palladium 10% on activated carbon; hydrazine hydrate; In ethanol; Reflux;

In ethanol; acetone; for 0.333333h; Reflux;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: 1335387-17-1
C₁₅H₁₉ClINO₃

: 1335387-04-6
(S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate / ethanol / -78 °C

2.1: potassium carbonate / methanol

3.1: ethanol

4.1: sodium hydrogencarbonate / dichloromethane; water

5.1: hydrogenchloride / 1,4-dioxane

6.1: bis(trichloromethyl) carbonate; triethylamine / dichloromethane

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 110 - 120 °C / Microwave irradiation

8.1: palladium 10% on activated carbon; hydrazine hydrate / ethanol / Reflux

8.2: 0.33 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(trichloromethyl) carbonate; palladium 10% on activated carbon; sodium hydrogencarbonate; potassium carbonate; hydrazine hydrate; triethylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile; 7.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: 1335387-30-8
C₂₅H₃₂IN₃O₈S

: 1335387-04-6
(S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 110 - 120 °C / Microwave irradiation

2.1: palladium 10% on activated carbon; hydrazine hydrate / ethanol / Reflux

2.2: 0.33 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; potassium carbonate; hydrazine hydrate; In ethanol; water; acetonitrile; 1.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037