3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride

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Chemical Name:3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride
CAS No.:1055305-19-5
Molecular Formula:C₁₈H₁₅FN₄O₂S*ClH
Molecular Weight:406.868
Hs Code.:

Synonyms:3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride

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Chemical Property of 3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride

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Technology Process of 3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride

There total 10 articles about 3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1055306-82-5
tert-butyl {[5-(2-cyanopyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

: 1055305-19-5
3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride

Guidance literature:: With hydrogenchloride; ethanol; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

: 1055306-64-3
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

: 1055305-19-5
3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

1.2: 3 h / -78 °C

2.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

3.2: 0.5 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

4.2: 0.5 h / 0 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

5.2: 14 h / 0 °C / Heating / reflux

5.3: 1 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 32 h / 120 °C

7.1: hydrogenchloride; ethanol / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; n-butyllithium; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydride; acetic acid; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 2-chloro-3-(4,4-difluoro-3-methylene-3,4-dihydro-2H-pyrrol-5-yl)pyridine

: 1055305-19-5
3-[3-fluoro-4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl]pyridine-2-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

1.2: 0.5 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.5 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 1 h / 0 °C

3.2: 14 h / 0 °C / Heating / reflux

3.3: 1 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 32 h / 120 °C

5.1: hydrogenchloride; ethanol / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; ethanol; carbonochloridic acid 1-chloro-ethyl ester; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;