2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Base Information

• Chemical Name: 2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
• CAS No.: 1622931-24-1
• Molecular Formula: C₁₈H₁₁ClF₆N₂OS
• Molecular Weight: 452.808
• Mol file: 1622931-24-1.mol

Synonyms:2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Chemical Property of 2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

There total 3 articles about 2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)thiourea (1622931-27-4) + 4-chlorobenzoylmethyl bromide (536-38-9) → 2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1622931-24-1)

Guidance literature:

In ethanol; at 80 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.07.025

Reference yield:

N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenylcarbamothioyl)benzamide (1622931-28-5) → 2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1622931-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 1 h / 100 °C

2: ethanol / 0.5 h / 80 °C / Microwave irradiation

With sodium hydroxide; In ethanol; water; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.ejmech.2014.07.025

Reference yield:

para-chloroacetophenone (99-91-2) → 2-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1622931-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / chloroform / 2 h / 0 - 20 °C

2: ethanol / 0.5 h / 80 °C / Microwave irradiation

With bromine; In ethanol; chloroform; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.ejmech.2014.07.025

upstream raw materials:

para-chloroacetophenone

N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenylcarbamothioyl)benzamide

1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)thiourea

4-chlorobenzoylmethyl bromide