Multi-step reaction with 9 steps
1.1: acetic acid / dichloromethane / 0.5 h / 40 °C / Industry scale; Inert atmosphere
1.2: 5 °C
2.1: tetrahydrofuran / 16 h / 15 - 20 °C
3.1: acetic acid / 24 h / 92 °C / Industry scale; Inert atmosphere
4.1: N,N-dimethyl-aniline; phosphorus trichloride / toluene / 16 h / 110 °C / Industry scale; Inert atmosphere
4.2: 25 °C / pH > 12
5.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere; 3 ? molecular sieve
5.2: 36 h / -20 - 30 °C / pH > 12
6.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Industry scale; Autoclave
7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere
8.1: aluminum (III) chloride / methoxybenzene / 16 h / 70 °C / Inert atmosphere
9.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h
9.2: 20 °C
With
4-methyl-morpholine; aluminum (III) chloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N,N-dimethyl-aniline; phosphorus trichloride;
platinum(IV) oxide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; methoxybenzene; N,N-dimethyl-formamide; toluene;