methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate

Base Information

• Chemical Name: methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate
• CAS No.: 861908-51-2
• Molecular Formula: C₂₃H₂₁N₃O₄S
• Molecular Weight: 435.503
• Mol file: 861908-51-2.mol

Synonyms:methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate

Chemical Property of methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate

There total 1 articles about methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl diazoacetate (6832-16-2) + N-([1,1'-biphenyl]-4-ylmethylene)-4-methylbenzenesulfonamide → methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate (861908-51-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 1h;

DOI:10.1016/j.tet.2005.04.054

Reference yield:

methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate (861908-51-2) → 3-biphenyl-4-yl-2-oxo-3-(toluene-4-sulfonylamino)-propionic acid methyl ester (861908-99-8)

Guidance literature:

With oxone; sodium hydrogencarbonate; In water; acetone; benzene; at 0 ℃;

DOI:10.1016/j.tet.2005.04.054

Reference yield:

methyl 2-diazo-3-(p-phenyl)phenyl-3-[(N-tosyl)amino]propanoate (861908-51-2) → methyl 2-hydroxy-3-(p-phenyl)phenyl-3'-(N-tosylamino)propanoate

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃; potassium peroxomonosulfate / benzene; acetone; H₂O / 0 °C

2: 92 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / 760 Torr

With oxone; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; water; acetone; benzene;

DOI:10.1016/j.tet.2005.04.054

upstream raw materials:

methyl diazoacetate

Downstream raw materials:

3-biphenyl-4-yl-2-oxo-3-(toluene-4-sulfonylamino)-propionic acid methyl ester