1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one

Base Information

• Chemical Name: 1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one
• CAS No.: 173375-21-8
• Molecular Formula: C₁₉H₁₃N₃O₄
• Molecular Weight: 347.33
• Mol file: 173375-21-8.mol

Synonyms:1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one

Chemical Property of 1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one

There total 1 articles about 1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-methyl-1,3-dihydro-imidazol-2-one (1192-34-3) + 4–(1,3-dioxoisoindolin-2-yl)benzoyl chloride (5383-83-5) → 1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one (173375-21-8)

Guidance literature:

With aluminium trichloride; In nitrobenzene; at 60 ℃; for 6h;

DOI:10.1002/ardp.19953281005

Reference yield: 85.0%

1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one (173375-21-8) → 4-(4-Aminobenzoyl)-1,3-dihydro-5-methyl-3H-imidazol-2-one (173375-23-0)

Guidance literature:

With sodium carbonate; hydrazine hydrate; for 10h; Ambient temperature;

DOI:10.1002/ardp.19953281005

Reference yield:

1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one (173375-21-8) → C18H20N6O2

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / 1 M aq. Na₂CO₃, hydrazine hydrate / 10 h / Ambient temperature

2: 95 percent / pyridine / 5 h / Ambient temperature

3: 91 percent / various solvent(s) / 12 h / Heating

With pyridine; sodium carbonate; hydrazine hydrate; In various solvent(s);

DOI:10.1002/ardp.19953281005

upstream raw materials:

4-methyl-1,3-dihydro-imidazol-2-one

4–(1,3-dioxoisoindolin-2-yl)benzoyl chloride

Downstream raw materials:

4-(4-Aminobenzoyl)-1,3-dihydro-5-methyl-3H-imidazol-2-one

2-<4-<(1,3-Dihydro-5-methyl-2-oxo-3H-imidazol-4-yl)carbonyl>phenyl>hydrazonopropanedinitrile

4-Chloro-N-[4-(5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-butyramide