N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide

Base Information

Chemical Name:N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide
CAS No.:1024583-17-2
Molecular Formula:C₃₄H₃₈N₆O₆
Molecular Weight:626.712
Hs Code.:

Synonyms:N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide

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Chemical Property of N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide

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Technology Process of N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide

There total 6 articles about N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911418-61-6
tert-butyl 5-(2-(3-butyramidophenyl)-6-hydroxy-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 6482-24-2
2-Bromoethyl methyl ether

: 1024583-17-2
N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 75 ℃; for 1.5h;

Reference yield:

: 911418-39-8
tert-butyl 5-(2-(3-butyramidophenyl)-6-hydroxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 6482-24-2
2-Bromoethyl methyl ether

: 1024583-17-2
N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 75 ℃; for 1.5h;

Reference yield:

: 911418-47-8
4-chloro-7-methoxy-2-(3-nitrophenyl)quinazolin-6-yl acetate

: 1024583-17-2
N-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenyl)butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 5 h / Heating / reflux

2: hydrogen / palladium over charcoal / methanol / 48 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 - 84 h / 20 °C

4: methanol; ammonia; water / 24 h / 20 °C

5: potassium carbonate / dimethyl sulfoxide / 1.5 h / 75 °C

With methanol; ammonia; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium over charcoal; In methanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;