8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

Base Information

Chemical Name:8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one
CAS No.:1026612-07-6
Molecular Formula:C₃₀H₄₀N₂O₅Si
Molecular Weight:536.744
Hs Code.:

8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[<i>cd</i>]phenalen-5-one

Synonyms:8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

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Chemical Property of 8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

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Technology Process of 8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

There total 8 articles about 8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 222969-16-6
6-[hydroxy-(4-methoxymethoxy-phenyl)-methyl]-7-methoxy-1-triisopropylsilanyl-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinoline-5-carboxylic acid tert-butyl ester

: 1026612-07-6
8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1016/S0040-4039(99)00034-9

Reference yield:

: 212829-60-2
(6-Methoxy-1-triisopropylsilanyl-1H-indol-3-ylmethyl)-dimethyl-amine

: 1026612-07-6
8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) t-BuLi, 2.) Cl₃CCCl₃ / 1.) Et₂O, 0 deg C, 1 h

2: 78 percent / toluene / 15 h / 0 °C

3: 80 percent / toluene / 0.33 h / 0 °C

4: 96 percent / LiAlH₄ / benzene; diethyl ether / 0.5 h / Heating

5: 70 percent / lithium isopropylcyclohexylamide / tetrahydrofuran / 0.25 h / 0 °C

6: 96 percent / 8 h / Heating

7: 1.) s-BuLi, TMEDA / 1.) Et₂O, -78 deg C, 1 h

8: 86 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; hexachloroethane; tert.-butyl lithium; sec.-butyllithium; sodium hydride; lithium cyclohexylisopropylamide; In tetrahydrofuran; diethyl ether; toluene; benzene;
DOI:10.1016/S0040-4039(99)00034-9

Reference yield:

: 212829-61-3
(4-Chloro-6-methoxy-1-triisopropylsilanyl-1H-indol-3-ylmethyl)-dimethyl-amine

: 1026612-07-6
8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / toluene / 15 h / 0 °C

2: 80 percent / toluene / 0.33 h / 0 °C

3: 96 percent / LiAlH₄ / benzene; diethyl ether / 0.5 h / Heating

4: 70 percent / lithium isopropylcyclohexylamide / tetrahydrofuran / 0.25 h / 0 °C

5: 96 percent / 8 h / Heating

6: 1.) s-BuLi, TMEDA / 1.) Et₂O, -78 deg C, 1 h

7: 86 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; lithium cyclohexylisopropylamide; In tetrahydrofuran; diethyl ether; toluene; benzene;
DOI:10.1016/S0040-4039(99)00034-9