4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine

Base Information

Chemical Name:4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine
CAS No.:328553-90-8
Molecular Formula:C₁₆H₁₃F₂N₃O₂S
Molecular Weight:349.361
Hs Code.:

4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1<i>H</i>-pyrazol-3-ylamine

Synonyms:4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine

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Chemical Property of 4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine

Chemical Property:

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Technology Process of 4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine

There total 3 articles about 4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-3-Chloro-2-(2,4-difluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylonitrile

: 328553-90-8
4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine

Guidance literature:: With hydrazine hydrate; In ethanol; at 78 ℃; for 18h;
DOI:10.1021/jm0009383

Reference yield:

: 708276-18-0
2-(2,4-difluorophenyl)-1-(4-methylsulfanylphenyl)ethanone

: 328553-90-8
4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxone / methanol; tetrahydrofuran / 1 h / 20 °C

2.1: POCl₃ / 0.25 h / 0 °C

2.2: CHCl₃ / 18 h / 80 °C

2.3: NH₂OH*HCl / dimethylformamide / 4 h / 20 °C

3.1: NH₂NH₂*H₂O / ethanol / 18 h / 78 °C

With Oxone; hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm0009383

Reference yield:

: 708276-26-0
2-(2,4-difluorophenyl)-1-(4-methanesulfonylphenyl)ethanone

: 328553-90-8
4-(2,4-difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: POCl₃ / 0.25 h / 0 °C

1.2: CHCl₃ / 18 h / 80 °C

1.3: NH₂OH*HCl / dimethylformamide / 4 h / 20 °C

2.1: NH₂NH₂*H₂O / ethanol / 18 h / 78 °C

With hydrazine hydrate; trichlorophosphate; In ethanol;
DOI:10.1021/jm0009383