4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Base Information

Chemical Name:4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS No.:1303588-35-3
Molecular Formula:C₁₇H₁₇F₃N₂
Molecular Weight:306.331
Hs Code.:

Synonyms:4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Suppliers and Price of 4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

There total 6 articles about 4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1303588-34-2
7-chloro-4 ,4-dimethyl-1,2,3,4-tetrahydro-1,8-naphthyridine

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1303588-35-3
4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 90 ℃;

Reference yield:

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 1303588-35-3
4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C

2.1: aluminum (III) chloride; methanesulfonic acid / dichloromethane / 20 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h

3.2: 2 h

3.3: pH 9 - 10

4.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

4.3: Inert atmosphere

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 90 °C

With hydrogenchloride; aluminum (III) chloride; methanesulfonic acid; boron trifluoride diethyl etherate; caesium carbonate; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 141-86-6
2.6-diaminopyridine

: 1303588-35-3
4,4-dimethyl-7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C

2.1: aluminum (III) chloride; methanesulfonic acid / dichloromethane / 20 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h

3.2: 2 h

3.3: pH 9 - 10

4.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

4.3: Inert atmosphere

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 90 °C

With hydrogenchloride; aluminum (III) chloride; methanesulfonic acid; boron trifluoride diethyl etherate; caesium carbonate; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;