Technology Process of 2-(2-((1S,5R)-2-((4-methoxybenzyloxy)methyl)-1,5-dimethylcyclopent-2-enyl)ethyl)-2-methyl-1,3-dioxolane
There total 9 articles about 2-(2-((1S,5R)-2-((4-methoxybenzyloxy)methyl)-1,5-dimethylcyclopent-2-enyl)ethyl)-2-methyl-1,3-dioxolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,5R)-2-((4-methoxybenzyloxy)methyl)-5-methyl-1-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclopent-2-enecarbaldehyde;
With
hydrazine;
In
ethylene glycol;
at 130 ℃;
for 0.5h;
With
potassium hydroxide;
In
ethylene glycol;
at 230 ℃;
for 3h;
DOI:10.1021/ol1026816
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 16 h / 45 °C / 760.05 Torr
2.1: diisobutylaluminium hydride / hexane / 4 h / -78 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 15 h / 0 - 20 °C
4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve
5.1: hydrazine / ethylene glycol / 0.5 h / 130 °C
5.2: 3 h / 230 °C
With
tetrapropylammonium perruthennate; palladium diacetate; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; hydrazine;
In
tetrahydrofuran; hexane; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; mineral oil;
5.2: Wolff-Kishner reduction;
DOI:10.1021/ol1026816
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / hexane / 4 h / -78 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 15 h / 0 - 20 °C
3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve
4.1: hydrazine / ethylene glycol / 0.5 h / 130 °C
4.2: 3 h / 230 °C
With
tetrapropylammonium perruthennate; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; hydrazine;
In
tetrahydrofuran; hexane; dichloromethane; ethylene glycol; mineral oil;
4.2: Wolff-Kishner reduction;
DOI:10.1021/ol1026816
