diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate

Base Information

Chemical Name:diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate
CAS No.:852949-68-9
Molecular Formula:C₂₄H₃₁O₅P
Molecular Weight:430.481
Hs Code.:

Synonyms:diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate

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Chemical Property of diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate

Chemical Property:

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Technology Process of diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate

There total 7 articles about diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 852949-67-8
3,5-dimethyl-2-iodo-4-(4'-methoxymethoxy-3'-iso-propylbenzyl)phenol

: 4851-51-8
diethyl ethynylphosphonate

: 852949-68-9
diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate

Guidance literature:: With copper(I) oxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 90 ℃; for 48h;

Reference yield:

: (4-methoxymethoxy-3-iso-propylphenyl)-(2,6-dimethyl-4-triisopropylsilyloxy)-methanol

: 852949-68-9
diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / acetic acid; ethyl acetate / 3 h / 20 °C

2.1: tetraethylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.2: 0.25 h

3.1: iodine; methylamine; potassium iodide / ethanol; water / 1 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine / copper(I) oxide / N,N-dimethyl-formamide / 48 h / 90 °C

With hydrogen; iodine; tetraethylammonium fluoride; N-ethyl-N,N-diisopropylamine; methylamine; potassium iodide; copper(I) oxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 7463-51-6
4-bromo-3,5-dimethylphenol

: 852949-68-9
diethyl [4,6-dimethyl-5-(4'-hydroxy-3'-iso-propyl)benzyl]benzofuran-2-phosphonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / dichloromethane / 2.67 h / 10 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; water / 4 h / -73 - -70 °C

2.2: 1.08 h / -73 - -70 °C

3.1: n-butyllithium / tetrahydrofuran / 1.75 h / -75 - -70 °C

3.2: 3 h / -75 - -70 °C

4.1: hydrogen / palladium 10% on activated carbon / acetic acid; ethyl acetate / 3 h / 20 °C

5.1: tetraethylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5.2: 0.25 h

6.1: iodine; methylamine; potassium iodide / ethanol; water / 1 h / 0 °C

7.1: N-ethyl-N,N-diisopropylamine / copper(I) oxide / N,N-dimethyl-formamide / 48 h / 90 °C

With 1H-imidazole; n-butyllithium; hydrogen; iodine; tetraethylammonium fluoride; N-ethyl-N,N-diisopropylamine; methylamine; potassium iodide; copper(I) oxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;