tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate
CAS No.:1236031-00-7
Molecular Formula:C₂₅H₃₆BrF₃N₂O₃SSi
Molecular Weight:609.623
Hs Code.:

Synonyms:tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

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Technology Process of tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

There total 1 articles about tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1236030-99-1
tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(thiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

: 1236031-00-7
tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 63.0%

: 1105710-34-6
3-fluoroisoquinolin-6-ylboronic acid

: 1236031-00-7
tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-bromothiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

: 1236031-01-8
tert-butyl (1S,2R)-1-(tert-butyldimethylsilyloxy)-4-(5-(3-fluoroisoquinolin-6-yl)thiazol-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate

Guidance literature:: With potassium acetate; bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; In water; acetonitrile; at 90 ℃; for 1h; Inert atmosphere; Microwave irradiation;