6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one

Base Information

• Chemical Name: 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one
• CAS No.: 1243253-47-5
• Molecular Formula: C₁₅H₁₇ClN₂O₄
• Molecular Weight: 324.764

Synonyms:6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one

Chemical Property of 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one

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Technology Process of 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one

There total 1 articles about 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

6-Chloro-3,4-dihydro-4-oxopyrimidine (4765-77-9) + 4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenylboronic acid (1243253-32-8) → 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one (1243253-47-5)

Guidance literature:

With pyridine; copper(II) acetate monohydrate; In dichloromethane; at 20 ℃; for 21h;

Reference yield: 69.1%

6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one (1243253-47-5) + 4-ethylphenylboronic acid (63139-21-9) → 6-(4-ethylphenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrimidin-4(3H)-one (1243253-13-5)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃;

Reference yield: 61.8%

6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one (1243253-47-5) + (4-fluorophenyl)methanethiol (15894-04-9) → C22H23FN2O4S (1243252-93-8)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 70 ℃;

upstream raw materials:

6-Chloro-3,4-dihydro-4-oxopyrimidine

4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenylboronic acid

Downstream raw materials:

C₂₂H₂₃FN₂O₄S

6-(4-chlorobenzyloxy)-3-(4-(2-hydroxy-2-methyl-propoxy)-3-methoxyphenyl)pyrimidin-4(3H)-one

6-(4-ethylphenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrimidin-4(3H)-one

(E)-6-(4-chlorostyryl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrimidin-4(3H)-one

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