4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide

Base Information

• Chemical Name: 4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide
• CAS No.: 398526-26-6
• Molecular Formula: C₃₂H₄₉N₅O₆S
• Molecular Weight: 631.837

Synonyms:4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide

Chemical Property of 4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide

There total 10 articles about 4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

((7S,10S,13S)-13-{(R)-2-[(4-Acetylamino-benzenesulfonyl)-(3-methyl-butyl)-amino]-1-hydroxy-ethyl}-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-7-yl)-carbamic acid tert-butyl ester (398526-27-7) → 4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide (398526-26-6)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

DOI:10.1021/jm010414i

Reference yield:

(7S,10S,13S)-7-tert-Butoxycarbonylamino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-triene-13-carboxylic acid methyl ester → 4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide (398526-26-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 81 percent / aq. NaOH / methanol / 1 h / 0 °C

2: N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3: tetrahydrofuran; diethyl ether / 0.5 h

4: 69 percent / HBr / ethyl acetate; tetrahydrofuran / -10 °C

5: 36 percent / NaBH₄ / ethanol / 0.08 h / -15 °C

6: 85 percent / NaOMe / tetrahydrofuran; methanol / 0.25 h / 20 °C

7: 94 percent / DIPEA / ethanol / Heating

8: 44 percent / DIPEA / tetrahydrofuran; H₂O / 0.5 h / 20 °C

9: 60 percent / aq. HCl / methanol / 2 h / Heating

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; hydrogen bromide; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; ethyl acetate;

DOI:10.1021/jm010414i

Reference yield:

[(7S,10S,13S)-13-((S)-2-Bromo-1-hydroxy-ethyl)-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-7-yl]-carbamic acid tert-butyl ester → 4-Amino-N-[(R)-2-((7S,10S,13S)-7-amino-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-13-yl)-2-hydroxy-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide (398526-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / NaOMe / tetrahydrofuran; methanol / 0.25 h / 20 °C

2: 94 percent / DIPEA / ethanol / Heating

3: 44 percent / DIPEA / tetrahydrofuran; H₂O / 0.5 h / 20 °C

4: 60 percent / aq. HCl / methanol / 2 h / Heating

With hydrogenchloride; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1021/jm010414i

upstream raw materials:

((7S,10S,13S)-13-{(R)-2-[(4-Acetylamino-benzenesulfonyl)-(3-methyl-butyl)-amino]-1-hydroxy-ethyl}-10-isopropyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-7-yl)-carbamic acid tert-butyl ester

1-amino-3-methylbutane

t-Boc-L-valine

Valyl-tyrosine Methyl Ester

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