(R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1384514-56-0
Molecular Formula:C₄₃H₅₈BrF₃O₁₁SSi
Molecular Weight:947.978
Hs Code.:

(R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Synonyms:(R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Chemical Property of (R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 8 articles about (R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1384514-54-8
((2S,3S,5R)-3-(4-bromobenzyloxy)-5-((1R,3S,4R)-1-hydroxy-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl)tetrahydrofuran-2-yl)methyl methanesulfonate

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 1384514-56-0
(R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ja304554e

Reference yield:

: 1384514-51-5
(1S,3R,4R,6S,7R)-1-(4-bromobenzyloxy)-6-(4-methoxybenzyloxy)-1-((R)-oxiran-2-yl)-7-(triethylsilyloxy)nonane-3,4-diol

: 1384514-56-0
(R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: camphor-10-sulfonic acid / dichloromethane / 3 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With dmap; camphor-10-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1021/ja304554e

Reference yield:

: 1384514-52-6
(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexan-1-ol

: 1384514-56-0
(R)-(1R,3S,4R)-1-((2R,4S,5S)-4-(4-bromobenzyloxy)-5-((methylsulfonyloxy)methyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyloxy)-4-(triethylsilyloxy)hexyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With dmap; triethylamine; In dichloromethane;
DOI:10.1021/ja304554e