(R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol

Base Information

Chemical Name:(R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol
CAS No.:955033-95-1
Molecular Formula:C₁₆H₁₆ClNO₃S
Molecular Weight:337.827
Hs Code.:

Synonyms:(R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol

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Chemical Property of (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol

Chemical Property:

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Technology Process of (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol

There total 7 articles about (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (R)-1-((4-chlorophenyl)sulfonyl)-2-(methoxymethyl)-1,2,3,4-tetrahydroquinoline

: 955033-95-1
(R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol

Guidance literature:: With 15-crown-5; boron tribromide; sodium iodide; In dichloromethane; at -30 ℃; Inert atmosphere;
DOI:10.1002/anie.202013540

Reference yield:

: 93-10-7,1199266-78-8
quinoline-2-carboxylic acid

: 955033-95-1
(R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: H₂ / PtO₂ / methanol

1.2: SOCl₂

2.1: LAH / tetrahydrofuran

3.1: Et₃N / CH₂Cl₂ / 0 °C

4.1: Et₃N / tetrahydrofuran / Heating

5.1: K₂CO₃; MeOH / 0 °C

6.1: chiral HPLC

With methanol; lithium aluminium tetrahydride; hydrogen; potassium carbonate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.09.064

Reference yield:

: 957467-72-0
2-trimethylsilanyloxymethyl-1,2,3,4-tetrahydro-quinoline

: 955033-95-1
(R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / Heating

2: K₂CO₃; MeOH / 0 °C

3: chiral HPLC

With methanol; potassium carbonate; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.09.064