(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester
CAS No.:648934-54-7
Molecular Formula:C₂₇H₄₂N₄O₅
Molecular Weight:502.654
Hs Code.:

(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Synonyms:(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Suppliers and Price of (3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

There total 11 articles about (3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 648934-49-0
(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2,4-dicarboxylic acid 4-benzyl ester 2-tert-butyl ester

: 648934-54-7
(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.bmcl.2005.01.022

Reference yield:

: 5211-24-5
(2S)-2,5-dihydro-1H-pyrrole-1,2-dicarboxylic acid 2-methyl 1-(phenylmethyl) ester

: 648934-54-7
(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 90 percent / LiBH₄ / methanol; tetrahydrofuran

2: Et₃N / CH₂Cl₂

3: sodium azide / dimethylformamide / 110 °C

4: 74 percent / PPh₃; H₂O / dioxane / 50 °C

5: 36 percent / CH₂Cl₂

6: 79 percent / Et₃N / methanol / 60 °C

7: 97 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂

8: 63 percent / dimethylformamide

9: 96 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂

10: 84 percent / HBTU; HOBT; NMM / dimethylformamide

11: 62 percent / m-chloroperoxybenzoic acid / CH₂Cl₂

12: 42 percent / potassium carbonate / acetonitrile / 60 °C

13: H₂ / Pd/C / ethanol

With 4-methyl-morpholine; lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; phenylsilane; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.01.022

Reference yield:

: 648934-22-9
(S)-2-azidomethyl-2,5-dihydropyrrole-1-carboxylic acid benzyl ester

: 648934-54-7
(3aR,6S,6aS)-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 74 percent / PPh₃; H₂O / dioxane / 50 °C

2: 36 percent / CH₂Cl₂

3: 79 percent / Et₃N / methanol / 60 °C

4: 97 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂

5: 63 percent / dimethylformamide

6: 96 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂

7: 84 percent / HBTU; HOBT; NMM / dimethylformamide

8: 62 percent / m-chloroperoxybenzoic acid / CH₂Cl₂

9: 42 percent / potassium carbonate / acetonitrile / 60 °C

10: H₂ / Pd/C / ethanol

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.01.022