diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate

Base Information

Chemical Name:diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate
CAS No.:921228-63-9
Molecular Formula:C₂₄H₂₉FNO₆P
Molecular Weight:477.47
Hs Code.:

Synonyms:diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate

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Technology Process of diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate

There total 3 articles about diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 921228-61-7
diisopropyl (1-benzyloxy-2,5-dioxopyrrolidin-3-yl)phosphonate

: 921228-63-9
diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 1.5h;
DOI:10.1071/CH06058

Reference yield:

: 32366-04-4
1-benzyloxy-3-bromopyrrolidine-2,5-dione

: 921228-63-9
diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / 2 h / 140 °C

2: 78 percent / sodium hydride / tetrahydrofuran / 1.5 h

With sodium hydride; In tetrahydrofuran; 1: Michaelis-Arbuzov reaction;
DOI:10.1071/CH06058

Reference yield:

: 116-17-6
triisopropyl phosphite

: 921228-63-9
diisopropyl [3-(4-fluorobenzyl)-1-benzyloxy-2,5-dioxopyrrolidin-3-yl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / 2 h / 140 °C

2: 78 percent / sodium hydride / tetrahydrofuran / 1.5 h

With sodium hydride; In tetrahydrofuran; 1: Michaelis-Arbuzov reaction;
DOI:10.1071/CH06058