2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide

Base Information

Chemical Name:2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide
CAS No.:929561-51-3
Molecular Formula:C₂₁H₂₀ClN₃O₅S
Molecular Weight:461.926
Hs Code.:

Synonyms:2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide

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Chemical Property of 2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide

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Technology Process of 2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide

There total 5 articles about 2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929562-39-0
C₂₁H₁₈ClN₃O₄S

: 929561-51-3
2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

Reference yield:

: 4629-54-3
2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone

: 929561-51-3
2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 4 h / Reflux

1.2: 0.5 h

2.1: triethylamine / tetrahydrofuran / 0.05 h / 120 °C / Microwave irradiation

3.1: boron trifluoride diethyl etherate / dichloromethane / 2.75 h / 20 °C / Cooling with acetone-dry ice

4.1: sodium hydroxide; dihydrogen peroxide / dimethyl sulfoxide / 0.5 h / 20 °C

With boron trifluoride diethyl etherate; dihydrogen peroxide; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 72806-64-5
(5-chloro-2,4-dimethoxyphenyl)-thiourea

: 929561-51-3
2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-thiazoleacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 4 h / Reflux

1.2: 0.5 h

2.1: triethylamine / tetrahydrofuran / 0.05 h / 120 °C / Microwave irradiation

3.1: boron trifluoride diethyl etherate / dichloromethane / 2.75 h / 20 °C / Cooling with acetone-dry ice

4.1: sodium hydroxide; dihydrogen peroxide / dimethyl sulfoxide / 0.5 h / 20 °C

With boron trifluoride diethyl etherate; dihydrogen peroxide; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;