2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

Base Information

Chemical Name:2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone
CAS No.:1190970-97-8
Molecular Formula:C₃₂H₃₄N₄O₆S
Molecular Weight:602.711
Hs Code.:

2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

Synonyms:2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

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Chemical Property of 2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

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Technology Process of 2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

There total 11 articles about 2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1190971-00-6
(S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)acetic acid

: 1190971-47-1
3-(pyridin-4-yl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine

: 1190970-97-8
2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

Guidance literature:: (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)acetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

3-(pyridin-4-yl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 1191265-66-3
((S)-1,2,3,4-tetrahydro-quinolin-2-yl)methanol hydrochloride

: 1190970-97-8
2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / dichloromethane / 0 - 20 °C

2.1: tetrabutyl-ammonium chloride; sodium hydroxide / toluene / 20 °C / Cooling with ice

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

4.2: 20 °C

With tetrabutyl-ammonium chloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; dmap; In dichloromethane; toluene;

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 1190970-97-8
2-[[(2S)-1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-quinolin-2-yl]-methoxy]-1-(3-pyridin-4-yl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-5-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux; Inert atmosphere

2.1: triethylamine / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere

3.1: sulfuric acid; water / 5 h / Reflux

3.2: Cooling with ice

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

4.2: 20 °C

With sulfuric acid; water; triethylamine; 1,1'-carbonyldiimidazole; toluene-4-sulfonic acid; In dichloromethane; toluene;