3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol

Base Information

Chemical Name:3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol
CAS No.:622347-36-8
Molecular Formula:C₁₄H₂₁NO₇
Molecular Weight:315.323
Hs Code.:

Synonyms:3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol

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Chemical Property of 3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol

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Technology Process of 3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol

There total 8 articles about 3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 622347-34-6
(4S)-4-benzyl-3-[3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropionyl]-oxazolidin-2-one

: 622347-36-8
3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol

Guidance literature:: With lithium borohydride; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1021/ol035400g

Reference yield:

: 13330-65-9
2,4-dimethoxyphenol

: 622347-36-8
3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / NaH / dimethylformamide / 14 h / 0 - 20 °C

2.1: TMEDA; n-BuLi / tetrahydrofuran; hexane / 4 h / 20 °C

2.2: 70 percent / tetrahydrofuran; hexane / 1 h

3.1: 88 percent / NH₄NO₃; TFAA / acetonitrile / 0.2 h / 0 °C

4.1: 99 percent / NaBH₄ / tetrahydrofuran / 1 h / 20 °C

5.1: 88 percent / LiBr; NEt₃; MsCl / tetrahydrofuran / 2 h / 0 °C

6.1: 87 percent / NaHMDS / tetrahydrofuran / 4 h / -78 °C

7.1: 80 percent / LiBH₄ / diethyl ether / 1 h / 0 °C

With ammonium nitrate; sodium tetrahydroborate; lithium borohydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hexamethyldisilazane; sodium hydride; methanesulfonyl chloride; triethylamine; trifluoroacetic anhydride; lithium bromide; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol035400g

Reference yield:

: 104202-36-0
1,3-dimethoxy-4-methoxymethoxybenzene

: 622347-36-8
3-(2,6-dimethoxy-3-methoxymethoxy-5-nitro-phenyl)-(2R)-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: TMEDA; n-BuLi / tetrahydrofuran; hexane / 4 h / 20 °C

1.2: 70 percent / tetrahydrofuran; hexane / 1 h

2.1: 88 percent / NH₄NO₃; TFAA / acetonitrile / 0.2 h / 0 °C

3.1: 99 percent / NaBH₄ / tetrahydrofuran / 1 h / 20 °C

4.1: 88 percent / LiBr; NEt₃; MsCl / tetrahydrofuran / 2 h / 0 °C

5.1: 87 percent / NaHMDS / tetrahydrofuran / 4 h / -78 °C

6.1: 80 percent / LiBH₄ / diethyl ether / 1 h / 0 °C

With ammonium nitrate; sodium tetrahydroborate; lithium borohydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hexamethyldisilazane; methanesulfonyl chloride; triethylamine; trifluoroacetic anhydride; lithium bromide; In tetrahydrofuran; diethyl ether; hexane; acetonitrile;
DOI:10.1021/ol035400g