N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide

Base Information

• Chemical Name: N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide
• CAS No.: 916765-79-2
• Molecular Formula: C₁₀H₁₃N₃O₃S₂
• Molecular Weight: 287.364
• Mol file: 916765-79-2.mol

Synonyms:N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide

Chemical Property of N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide

There total 2 articles about N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-(methylsulfonamido)phenyl)acetic acid (407640-21-5) → N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide (916765-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

2: tetrahydrofuran / Heating

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2006.09.053

Reference yield:

(3-methanesulfonylamino-phenyl)-acetyl chloride + thiourea (17356-08-0) → N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide (916765-79-2)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1016/j.tetlet.2006.09.053

Reference yield: 48.0%

1-(2-{[(4-methoxyphenyl)methyl]amino}pyridin-4-yl)ethan-1-one (916765-80-5) + N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide (916765-79-2) → N-[4-(2-amino-pyridin-4-yl)-thiazol-2-yl]-2-(3-methanesulfonylamino-phenyl)-acetamide

Guidance literature:

1-(2-{[(4-methoxyphenyl)methyl]amino}pyridin-4-yl)ethan-1-one; With hydrogen bromide; bromine; acetic acid; at 70 ℃; for 2h;

N-[3-(2-oxo-2-thioureido-ethyl)-phenyl]-methanesulfonamide; In ethanol; at 70 ℃; for 1h;

DOI:10.1016/j.tetlet.2006.09.053

upstream raw materials:

thiourea

2-(3-(methylsulfonamido)phenyl)acetic acid