3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide
CAS No.:1354947-82-2
Molecular Formula:C₁₅H₁₅F₃N₆O₂
Molecular Weight:368.318
Hs Code.:

Synonyms:3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide

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Chemical Property of 3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide

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Technology Process of 3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide

There total 6 articles about 3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354947-81-1
3-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-(trifluoromethyl)benzamide

: 31560-06-2
(1S,4S)-(+)-2-Aza-5-oxabicyclo[2.2.1]heptane hydrochloride

: 1354947-82-2
3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 140 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 54962-75-3
[3-bromo-5-(trifluoromethyl)phenyl]amine

: 1354947-82-2
3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 22 h / 20 °C / Cooling with ice

3: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 6 h / 50 °C

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 - 5 °C

5: thionyl chloride / toluene / 4 h / Reflux

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 140 °C / Microwave irradiation

With thionyl chloride; lithium hydroxide monohydrate; trimethylsilylazide; di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1354947-79-7
2-{[3-cyano-5-(trifluoromethyl)phenyl]amino}-2-oxoethyl acetate

: 1354947-82-2
3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 6 h / 50 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 - 5 °C

3: thionyl chloride / toluene / 4 h / Reflux

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 140 °C / Microwave irradiation

With thionyl chloride; lithium hydroxide monohydrate; trimethylsilylazide; di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; toluene; acetonitrile;