7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1446946-33-3
Molecular Formula:C₂₆H₂₆F₂N₄O₅
Molecular Weight:512.513
Hs Code.:

Synonyms:7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 3 articles about 7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 139693-52-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate

: 3-amino-4-(4'-fluorobenzyloxyimino)piperidine dihydrochloride

: 1446946-33-3
7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate; 3-amino-4-(4'-fluorobenzyloxyimino)piperidine dihydrochloride; With triethylamine; In acetonitrile; at 20 - 50 ℃;

With sodium hydroxide; In acetonitrile; at 50 ℃; for 1h;
DOI:10.3390/molecules18043872

Reference yield:

: 1446946-20-8
C₁₇H₂₄FN₃O₃

: 1446946-33-3
7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / dichloromethane / 1.5 h / 20 °C

2.1: triethylamine / acetonitrile / 20 - 50 °C

2.2: 1 h / 50 °C

With hydrogenchloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.3390/molecules18043872

Reference yield:

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1446946-33-3
7-[3-amino-4-(4'-fluorobenzyloxyimino)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: boric acid / 1.5 h / 110 °C

1.2: 1 h / 110 °C

1.3: 2 h / 95 - 110 °C

2.1: triethylamine / acetonitrile / 20 - 50 °C

2.2: 1 h / 50 °C

With boric acid; triethylamine; In acetonitrile;
DOI:10.3390/molecules18043872