4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate

Base Information

• Chemical Name: 4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate
• CAS No.: 1073282-34-4
• Molecular Formula: C₂₀H₁₇ClN₂O₄S
• Molecular Weight: 416.885
• Mol file: 1073282-34-4.mol

Synonyms:4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate

Chemical Property of 4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate

Chemical Property:

Purity/Quality:

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Technology Process of 4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate

There total 1 articles about 4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-amino-2-methoxyphenyl acetate (71573-23-4) + 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid (187949-86-6) → 4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate (1073282-34-4)

Guidance literature:

3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 2.3h;

4-amino-2-methoxyphenyl acetate; In 1-methyl-pyrrolidin-2-one; 1,2-dichloro-ethane; at 80 ℃; for 16h;

Reference yield: 94.0%

4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate (1073282-34-4) → 4-(6-(4-Chlorophenyl)-4-oxothieno[3,2-d][1,2,3]triazin-3(4H)-yl)-2-methoxyphenyl acetate (1073282-35-5)

Guidance literature:

4-(3-Amino-5-(4-chlorophenyl)thiophene-2-carboxamido)-2-methoxyphenyl acetate; With sodium nitrite; In water; acetic acid; at 20 ℃; for 2h;

With potassium carbonate; In water; acetic acid; pH=8;

upstream raw materials:

4-amino-2-methoxyphenyl acetate

3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid

Downstream raw materials:

4-(6-(4-Chlorophenyl)-4-oxothieno[3,2-d][1,2,3]triazin-3(4H)-yl)-2-methoxyphenyl acetate