(3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester
CAS No.:1169769-83-8
Molecular Formula:C₂₃H₂₆N₂O₆
Molecular Weight:426.469
Hs Code.:

Synonyms:(3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of (3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

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Technology Process of (3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

There total 3 articles about (3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1169769-83-8
(3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1394920-45-6
(3S)-tert-butyl 3-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

Guidance literature:: With quinine; In chloroform; at -20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2012.06.018

Reference yield:

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1169769-83-8
(3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 3-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With C₃₈H₂₆Mn₂N₂O₈; In tetrahydrofuran; ethyl acetate; at 20 - 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja903566u

Reference yield:

: 3179-10-0,5576-97-6
(E)-1-methoxy-4-(2-nitrovinyl)benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1169769-83-8
(3R)-3-[(1S)-1-(4-methoxy-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1394920-45-6
(3S)-tert-butyl 3-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

: C₂₃H₂₆N₂O₆

Guidance literature:: With C₆₂H₆₈N₆NiO₄⁽²⁺⁾*2BF₄^(1-); In dichloromethane; at 20 ℃; for 20h; Overall yield = 95 %; Overall yield = 98 %Spectr.; stereoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.201502930