(4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid

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Chemical Name:(4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid
CAS No.:1016237-81-2
Molecular Formula:C₂₁H₃₁N₅O₈
Molecular Weight:481.506
Hs Code.:

Synonyms:(4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid

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Chemical Property of (4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid

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Technology Process of (4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid

There total 5 articles about (4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1016237-79-8
t-butyl (4-tert-butoxycarbonylmethyl-7-{2-[tert-butoxycarbonylmethyl-(4-nitro-benzyl)-amino]ethyl}-[1,4,7]triazonan-1-yl)acetate

: 1016237-81-2
(4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;
DOI:10.1021/jm701307j

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1016237-81-2
(4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 120 h / 0 - 20 °C / Molecular sieve

2.1: sodium tetrahydroborate / ethanol / 21 h / 0 - 20 °C

3.1: potassium carbonate / acetonitrile / 22 h / 0 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.5 h / -60 °C

4.2: 0.5 h / -60 °C

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 18.2 h / 0 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; potassium carbonate; dimethyl sulfoxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; 4.1: |Swern Oxidation / 4.2: |Swern Oxidation;

Reference yield:

: 64834-64-6
2-(4-nitrobenzylbenzylamino)ethanol

: 1016237-81-2
(4-carboxymethyl-7-{2-[carboxymethyl-(4-nitro-benzyl)-amino]-ethyl}-[1,4,7]triazonan-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 22 h / 0 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.5 h / -60 °C

2.2: 0.5 h / -60 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 18.2 h / 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C / Cooling with ice

With hydrogenchloride; oxalyl dichloride; sodium tris(acetoxy)borohydride; potassium carbonate; dimethyl sulfoxide; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; acetonitrile; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;