7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester

Base Information

Chemical Name:7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester
CAS No.:808112-82-5
Molecular Formula:C₃₈H₆₇N₄O₉P
Molecular Weight:754.945
Hs Code.:

Synonyms:7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester

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Chemical Property of 7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester

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Technology Process of 7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester

There total 6 articles about 7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 178676-06-7
[bis(tert-butoxy)phosphoryl]methyl trifluoromethanesulfonate

: 857677-13-5
1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid 1,7-bis(1,1-dimethylethyl)4-(phenylmethyl)ester

: 808112-82-5
7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 40 ℃; for 6h; Product distribution / selectivity;

Reference yield: 58.0%

: 857677-15-7
4-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,7-diacetic acid di-t-butyl ester

: 5437-45-6
Benzyl bromoacetate

: 808112-82-5
7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 37h;
DOI:10.1055/s-0040-1707893

Reference yield:

: 120041-13-6
1-formaldehyde-1,4,7,10-tetraazadododecane

: 808112-82-5
7-[[di(t-butoxy)phosphoryl]methyl]-1,4,7,10-tetrazacyclododecane-1,4,10-triacetic acid 1-benzyl 4,10-di-t-butylester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium hydroxide / water; 1,4-dioxane / 4.5 h / pH 3

2.1: sodium hydroxide / water / 0.33 h

2.2: 22.5 h / 20 °C

3.1: hydroxylamine hydrochloride / ethanol / 48 h / Reflux

4.1: 36 h / 70 °C

5.1: hydrogen; 5%-palladium/activated carbon / methanol / 8 h / 20 °C

6.1: potassium carbonate / acetonitrile / 37 h / 20 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydroxylamine hydrochloride; hydrogen; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; acetonitrile; 4.1: |Kabachnik-Fields Reaction;
DOI:10.1055/s-0040-1707893