{(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

Base Information

Chemical Name:{(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester
CAS No.:162539-06-2
Molecular Formula:C₃₅H₄₇N₃O₆
Molecular Weight:605.775
Hs Code.:

Synonyms:{(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

Suppliers and Price of {(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

There total 10 articles about {(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 162539-06-2
{(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.33 h / -25 - -20 °C

2: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight

3: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C

4: NaBH₄ / tetrahydrofuran; H₂O / 0.75 h / 0 °C

5: 84 percent / KOH / ethanol / 1.5 h / Ambient temperature

6: 74 percent / dimethylformamide / 20 h / 105 °C

7: 165 mg / 4N aq. HCl / 1 h / 0 °C

8: diisopropylethylamine / dimethylformamide / 72 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00038a005

Reference yield:

: 60398-41-6
(3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate

: 162539-06-2
{(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C

2: NaBH₄ / tetrahydrofuran; H₂O / 0.75 h / 0 °C

3: 84 percent / KOH / ethanol / 1.5 h / Ambient temperature

4: 74 percent / dimethylformamide / 20 h / 105 °C

5: 165 mg / 4N aq. HCl / 1 h / 0 °C

6: diisopropylethylamine / dimethylformamide / 72 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00038a005

Reference yield:

: 67729-36-6,60398-40-5
Boc-Phe-O-COO-isoBu

: 162539-06-2
{(1S,2R)-1-Benzyl-3-[benzyl-((2R,3S)-2-hydroxy-3-isopropoxycarbonylamino-4-phenyl-butyl)-amino]-2-hydroxy-propyl}-carbamic acid isopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight

2: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C

3: NaBH₄ / tetrahydrofuran; H₂O / 0.75 h / 0 °C

4: 84 percent / KOH / ethanol / 1.5 h / Ambient temperature

5: 74 percent / dimethylformamide / 20 h / 105 °C

6: 165 mg / 4N aq. HCl / 1 h / 0 °C

7: diisopropylethylamine / dimethylformamide / 72 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00038a005