(S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1184174-63-7
Molecular Formula:C₄₃H₄₃N₅O₅
Molecular Weight:709.845
Hs Code.:

Synonyms:(S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 12 articles about (S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1184174-10-4
C₁₁H₁₉NO₅

: 1184174-62-6
3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylamine

: 1184174-63-7
(S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 942190-65-0
1-benzyl-3-methoxy-pyrrolidine-3-carboxylic acid methyl ester

: 1184174-63-7
(S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium on activated charcoal / ethanol / 24 h / 2844.39 Torr

2: methanol / 24 h

3: triethylamine / dichloromethane / 0 - 20 °C

4: methanol; water; lithium hydroxide / tetrahydrofuran / 20 °C

5: triethylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With methanol; water; hydrogen; triethylamine; HATU; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 942189-39-1
3-bromo-5-nitro-1-trityl-1H-indazole

: 1184174-63-7
(S)-3-methoxy-3-[3-(2-methoxy-pyridin-4-yl)-1-trityl-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 20 - 80 °C

2: toluene / 24 h / 70 °C / Inert atmosphere

3: hydrogen / palladium on activated charcoal / methanol; toluene / 20 °C

4: triethylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With potassium phosphate; hydrogen; triethylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;