4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid

Base Information

Chemical Name:4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid
CAS No.:1433280-22-8
Molecular Formula:C₂₉H₃₂N₄O₇
Molecular Weight:548.596
Hs Code.:

Synonyms:4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid

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Chemical Property of 4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid

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Technology Process of 4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid

There total 8 articles about 4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1256390-26-7
((S)-1-{(S)-8-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-1,4-dioxa-7-aza-spiro[4.4]nonane-7-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

: 14047-29-1
4-carboxyphenylboronic acid

: 1433280-22-8
4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; for 3h; Reflux;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1433280-22-8
4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; sodium carbonate / water / 0 - 20 °C

1.2: 1.5 h / pH Ca_. 1

2.1: HATU; triethylamine / dichloromethane / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: toluene-4-sulfonic acid / toluene / Reflux

5.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

5.2: pH 1

6.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

7.1: ammonium acetate / toluene / Reflux

8.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; water; sodium carbonate; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; HATU; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1433280-22-8
4'-{2-[(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]non-8-yl]-1H-imidazol-4-yl}-biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: HATU; triethylamine / dichloromethane / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: toluene-4-sulfonic acid / toluene / Reflux

4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4.2: pH 1

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

6.1: ammonium acetate / toluene / Reflux

7.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; water; sodium carbonate; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;