4-Amino-1-[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-propen-1-yl]oxy]methyl]-2(1H)-pyrimidinone

Base Information

Chemical Name:4-Amino-1-[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-propen-1-yl]oxy]methyl]-2(1H)-pyrimidinone
CAS No.:136083-16-4
Molecular Formula:C₂₅H₃₁N₃O₃Si
Molecular Weight:449.625
Hs Code.:
DSSTox Substance ID:DTXSID301109888

Synonyms:DTXSID301109888;136083-16-4;4-Amino-1-[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-propen-1-yl]oxy]methyl]-2(1H)-pyrimidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Amino-1-[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-propen-1-yl]oxy]methyl]-2(1H)-pyrimidinone

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:10
Exact Mass:449.21346839
Heavy Atom Count:32
Complexity:686

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OCC(C=C)OCN3C=CC(=NC3=O)N

Technology Process of 4-Amino-1-[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-propen-1-yl]oxy]methyl]-2(1H)-pyrimidinone

There total 4 articles about 4-Amino-1-[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-propen-1-yl]oxy]methyl]-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 73416-12-3
4-Amino-1-trimethylsilanyl-1H-pyrimidin-2-one

: 136083-14-2
(+/-)-1-tert-Butyldiphenylsilyloxy-2-acetoxymethylenoxybut-3-ene

: 136083-16-4
(+/-)1-<(1'-tert-Butyldiphenylsilyloxybut-3'-en-2'-yloxy)methyl>cytosine

Guidance literature:: With dibenzo-18-crown-6; potassium iodide; In toluene; acetonitrile; at 80 ℃; for 6h; solid-liquid phase transfer catalysis;

Reference yield:

: 177032-63-2
(+/-)-1-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-butene

: 136083-16-4
(+/-)1-<(1'-tert-Butyldiphenylsilyloxybut-3'-en-2'-yloxy)methyl>cytosine

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / P₂O₅ / CHCl₃ / 24 h / Ambient temperature

2: 95 percent / BF₃*Et₂O / diethyl ether / 48 h / 4 °C

3: 73 percent / dibenzo-18-crown-6 ether, KI / acetonitrile; toluene / 6 h / 80 °C / solid-liquid phase transfer catalysis

With dibenzo-18-crown-6; boron trifluoride diethyl etherate; phosphorus pentoxide; potassium iodide; In diethyl ether; chloroform; toluene; acetonitrile;

Reference yield:

: 136083-13-1
(+/-)-1-tert-Butyldiphenylsilyloxy-2-methoxymethylenoxybut-3-ene

: 136083-16-4
(+/-)1-<(1'-tert-Butyldiphenylsilyloxybut-3'-en-2'-yloxy)methyl>cytosine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / BF₃*Et₂O / diethyl ether / 48 h / 4 °C

2: 73 percent / dibenzo-18-crown-6 ether, KI / acetonitrile; toluene / 6 h / 80 °C / solid-liquid phase transfer catalysis

With dibenzo-18-crown-6; boron trifluoride diethyl etherate; potassium iodide; In diethyl ether; toluene; acetonitrile;