3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine

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Chemical Name:3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine
CAS No.:401494-92-6
Molecular Formula:C₄₄H₇₀N₁₀O₆
Molecular Weight:835.103
Hs Code.:

Synonyms:3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine

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Chemical Property of 3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine

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Technology Process of 3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine

There total 1 articles about 3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 400710-96-5
3-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentylamino}-propan-1-ol

: 401494-92-6
3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm0105070

Reference yield:

: 401494-92-6
3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine

: 3α,7α,12α-tris(3-aminopropoxy)-5β-cholan-24-(N-(N-(3-aminopropyl))-3-aminopropyl)amine

Guidance literature:: Multi-step reaction with 4 steps

1: 285 mg / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 76 percent / NaI; Na₂CO₃ / dimethylsulfoxide / 90 °C

3: H₂ / PtO₂ / ethanol / 48 h / 20 °C / 41372.9 Torr

4: 25.5 mg / H₂; AcOH / Pd(OH)2 / ethanol / 48 h / 41372.9 Torr

With hydrogen; sodium carbonate; acetic acid; triethylamine; sodium iodide; platinum(IV) oxide; palladium dihydroxide; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm0105070

Reference yield:

: 401494-92-6
3α,7α,12α-tris(3-azidopropoxy)-5β-cholan-24-(N-(benzyloxycarbonyl)-N-(3-hydroxypropyl))amine

: [3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-amino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 285 mg / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 76 percent / NaI; Na₂CO₃ / dimethylsulfoxide / 90 °C

3: H₂ / PtO₂ / ethanol / 48 h / 20 °C / 41372.9 Torr

With hydrogen; sodium carbonate; triethylamine; sodium iodide; platinum(IV) oxide; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm0105070