methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

Base Information

Chemical Name:methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate
CAS No.:144876-70-0
Molecular Formula:C₃₂H₃₅N₅O₆
Molecular Weight:585.66
Hs Code.:

methyl <R-(R*,R*)>-6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

Synonyms:methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

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Chemical Property of methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

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Technology Process of methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

There total 4 articles about methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 30988-17-1
methyl 2-isocyanatoacetate

: 144876-63-1
phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate

: 144876-70-0
methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

Guidance literature:: In tetrahydrofuran; toluene; at 80 - 100 ℃; for 16h;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 130406-36-9,142854-51-1
((S)-2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

: 144876-70-0
methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1) THF, EtOAc, 25 deg C, 2 h, 2) 25 deg C, 17 h

2: 80 percent / piperidine / dimethylformamide / 17 h / 0 °C

3: 79 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 134558-28-4
N-[(9H-fluoren-9-ylmethyloxy)-carbonyl]-α-methyl-DL-tryptophan

: 144876-70-0
methyl -6-(1H-indol-3-ylmethyl)-6-methyl-4,7,12-trioxo-10,14-diphenyl-13-oxa-3,5,8,11-tetraazatetradecanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1) THF, EtOAc, 25 deg C, 2 h, 2) 25 deg C, 17 h

2: 80 percent / piperidine / dimethylformamide / 17 h / 0 °C

3: 79 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)86596-0