trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid

Base Information

Chemical Name:trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid
CAS No.:1239311-11-5
Molecular Formula:C₂₃H₂₉N₃O₄S
Molecular Weight:443.567
Hs Code.:

Synonyms:trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid

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Chemical Property of trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid

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Technology Process of trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid

There total 7 articles about trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₇N₃O₄S

: 1239311-11-5
trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1.5h;

Reference yield:

: 1239311-12-6
tert-butyl trans-4-(4-chlorocarbonylphenyl)cyclohexaneacetate

: 1239311-11-5
trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice

2: acetonitrile / 38.5 h / 20 °C / Inert atmosphere; Reflux

3: trifluoroacetic acid / dichloromethane / 1.5 h

With trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 1237147-85-1
trans-4'-(4-tert-butoxycarbonylmethylcyclohexyl)benzoic acid

: 1239311-11-5
trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: acetonitrile / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice

3: acetonitrile / 38.5 h / 20 °C / Inert atmosphere; Reflux

4: trifluoroacetic acid / dichloromethane / 1.5 h

With oxalyl dichloride; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; acetonitrile;