2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide

Base Information

Chemical Name:2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide
CAS No.:1417526-08-9
Molecular Formula:C₁₆H₁₆FN₃O₂S
Molecular Weight:333.386
Hs Code.:

Synonyms:2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide

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Chemical Property of 2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide

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Technology Process of 2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide

There total 5 articles about 2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 356058-42-9
{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetic acid

: 1417526-08-9
2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide

Guidance literature:: {2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 0.5h; Cooling with ice;

With ammonia; In dichloromethane; water; for 0.166667h; Cooling with ice;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1417526-08-9
2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Reflux

3.1: water; lithium hydroxide monohydrate / isopropyl alcohol / 2 h / 20 °C

4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 0.5 h / Cooling with ice

4.2: 0.17 h / Cooling with ice

With thionyl chloride; lithium hydroxide monohydrate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium iodide; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetone;

Reference yield:

: 451487-18-6
2-[(4-fluorobenzyl)sulfanyl]-1,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one

: 1417526-08-9
2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Reflux

2.1: water; lithium hydroxide monohydrate / isopropyl alcohol / 2 h / 20 °C

3.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 0.5 h / Cooling with ice

3.2: 0.17 h / Cooling with ice

With thionyl chloride; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; isopropyl alcohol;