(Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

Base Information

Chemical Name:(Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid
CAS No.:1300092-85-6
Molecular Formula:C₃₁H₅₀O₉
Molecular Weight:566.733
Hs Code.:

Synonyms:(Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

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Chemical Property of (Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

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Technology Process of (Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

There total 8 articles about (Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300092-83-4
(3aR,4R,5R,6aS)-5-((2-methoxyethoxy)methoxy)-4-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-ol

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 1300092-85-6
(Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

Guidance literature:: (4-carboxybutyl)triphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere;

(3aR,4R,5R,6aS)-5-((2-methoxyethoxy)methoxy)-4-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-ol; In tetrahydrofuran; at 25 ℃; for 1.5h; Inert atmosphere;

With citric acid; In water; pH=5;

Reference yield:

: (3aR,4R,6aS)-2-oxo-4-((E)-3-oxo-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate

: 1300092-85-6
(Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

1.2: -20 - 0 °C / Inert atmosphere

1.3: pH 3

2.1: potassium carbonate; methanol / 2 h / 25 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 0 - 25 °C / Inert atmosphere

4.1: triethylamine; hydrogen / palladium on carbon / ethyl acetate / 2 h / 25 °C / 1471.14 Torr

5.1: diisobutylaluminium hydride / toluene / 1 h / -65 - -60 °C / Inert atmosphere

5.2: 1 h / 25 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

6.2: 1.5 h / 25 °C / Inert atmosphere

6.3: pH 5

With methanol; hydrogen; sodium hexamethyldisilazane; diisobutylaluminium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; palladium on carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;

Reference yield:

: (3aR,4R,6aS)-4-((S,E)-3-hydroxy-5-phenylpent-1-enyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate

: 1300092-85-6
(Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((2-methoxyethoxy)methoxy)-2-((R)-3-((2-methoxyethoxy)methoxy)-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; methanol / 2 h / 25 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 0 - 25 °C / Inert atmosphere

3.1: triethylamine; hydrogen / palladium on carbon / ethyl acetate / 2 h / 25 °C / 1471.14 Torr

4.1: diisobutylaluminium hydride / toluene / 1 h / -65 - -60 °C / Inert atmosphere

4.2: 1 h / 25 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

5.2: 1.5 h / 25 °C / Inert atmosphere

5.3: pH 5

With methanol; hydrogen; sodium hexamethyldisilazane; diisobutylaluminium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;