(1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

Base Information

Chemical Name:(1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol
CAS No.:136310-19-5
Molecular Formula:C₁₄H₁₈F₂O₂S
Molecular Weight:288.359
Hs Code.:

(1S,3S,6S,R<sub>S</sub>)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

Synonyms:(1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

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Chemical Property of (1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

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Technology Process of (1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

There total 3 articles about (1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 136377-22-5
(2R,3S,R_S)-1-chloro-1,1-difluoro-3-<(4-methylphenyl)sulphinyl>hept-6-en-2-ol

: 136310-20-8
(1S,3R,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

: 136310-19-5
(1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 70 ℃; for 5h;
DOI:10.1016/S0957-4166(00)82161-8

Reference yield:

: 136310-09-3,136310-10-6
(3RS,R_S)-1-Chloro-1,1-difluoro-3-<(4-methylphenyl)sulfinyl>hept-6-en-2-one

: 136310-19-5
(1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 14.6 percent / sodium borohydride, 30percent aq. ammonia / methanol / 0.17 h / 20 °C

2: 49 percent / AIBN, tributyltin hydride / benzene / 5 h / 70 °C

With ammonium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; benzene;
DOI:10.1021/jo00091a041

Reference yield:

: 1517-82-4
(-)-menthyl p-toluenesulfinate

: 136310-19-5
(1S,3S,6S,R_S)-2,2-Difluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / LDA / tetrahydrofuran / 0.08 h / -65 °C

2: 14.6 percent / sodium borohydride, 30percent aq. ammonia / methanol / 0.17 h / 20 °C

3: 49 percent / AIBN, tributyltin hydride / benzene / 5 h / 70 °C

With ammonium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/jo00091a041