N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide

Base Information

Chemical Name:N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide
CAS No.:185213-06-3
Molecular Formula:C₂₄H₂₉N₃O₄
Molecular Weight:423.512
Hs Code.:

Synonyms:N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide

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Chemical Property of N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide

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Technology Process of N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide

There total 4 articles about N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 185213-05-2
(2S)-indolinecarboxylic acid propylamide

: 42918-86-5,1145-79-5,2900-20-1,20395-87-3
(S)-2-(((benzyloxy)carbonyl)amino)butanoic acid

: 185213-06-3
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide

Guidance literature:: (S)-2-(((benzyloxy)carbonyl)amino)butanoic acid; With N-ethylmorpholine;; isobutyl chloroformate; In tetrahydrofuran; for 0.5h;

(2S)-indolinecarboxylic acid propylamide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm0500830

Reference yield:

: 42918-86-5,1145-79-5,2900-20-1,20395-87-3
(S)-2-(((benzyloxy)carbonyl)amino)butanoic acid

: 543-27-1
isobutyl chloroformate

: 185213-06-3
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide

Guidance literature:: With N-ethylmorpholine;; In (2S)-indolinecarboxylic acid propylamide; tetrahydrofuran;

Reference yield:

: 185213-04-1
N-benzyloxycarbonyl-(2S)-indolinecarboxylic acid propylamide

: 185213-06-3
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid propylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / H₂ / Pd/C / methanol / 3 h / 25 °C / 1551.44 Torr

2.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

2.2: 89 percent / tetrahydrofuran / 20 °C

With N-ethylmorpholine;; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0500830