N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide
CAS No.:1445803-75-7
Molecular Formula:C₂₁H₁₈ClF₄N₅O₃
Molecular Weight:499.852
Hs Code.:

Synonyms:N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide

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Chemical Property of N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide

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Technology Process of N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide

There total 10 articles about N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: [2-(2-amino-ethoxy)-4-fluoro-phenyl]-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]inden-2-yl)-methanone hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 1445803-75-7
N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.583333h;

Reference yield:

: 398491-59-3
3-amino-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

: 1445803-75-7
N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / 32 h / 20 °C

2: acetic acid; hydrogenchloride / water / 2 h / 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 145 °C / Microwave irradiation

5: hydrogenchloride / 1,4-dioxane / 0.25 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / 0 - 20 °C

With hydrogenchloride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1694-29-7
3-chloropentane-2,4-dione

: 1445803-75-7
N-{2-[2-(6-chloro-5,7-dimethyl-1H,3H-2,4,7a,8-tetraazacyclopenta[a]indene-2-carbonyl)-5-fluoro-phenoxy]-ethyl}-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / 32 h / 20 °C

2: acetic acid; hydrogenchloride / water / 2 h / 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 145 °C / Microwave irradiation

5: hydrogenchloride / 1,4-dioxane / 0.25 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / 0 - 20 °C

With hydrogenchloride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;