[2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester

Base Information

• Chemical Name: [2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester
• CAS No.: 134307-60-1
• Molecular Formula: C₁₄H₁₈ClNO₅
• Molecular Weight: 315.754
• Mol file: 134307-60-1.mol

Synonyms:[2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester

Chemical Property of [2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester

There total 3 articles about [2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methoxyphenyl)oxirane (62717-78-6,141303-38-0) → [2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester (134307-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 48 h

2: NaHCO₃ / CH₂Cl₂; H₂O / 0.17 h / Ambient temperature

With sodium hydrogencarbonate; In dichloromethane; water; benzene;

DOI:10.1016/S0040-4020(01)81795-6

Reference yield:

ortho-anisaldehyde (135-02-4) → [2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester (134307-60-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.5 percent / tetra-n-butylammonium iodide, 50percent aq. NaOH / CH₂Cl₂ / 120 h / Ambient temperature

2: benzene / 48 h

3: NaHCO₃ / CH₂Cl₂; H₂O / 0.17 h / Ambient temperature

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; In dichloromethane; water; benzene;

DOI:10.1016/S0040-4020(01)81795-6

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + C10H10Cl2O3 (134329-07-0) → [2-Chloro-2-(2-methoxy-phenyl)-ethoxycarbonylamino]-acetic acid ethyl ester (134307-60-1)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; for 0.166667h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4020(01)81795-6

upstream raw materials:

glycine ethyl ester hydrochloride

C₁₀H₁₀Cl₂O₃

2-(2-methoxyphenyl)oxirane

ortho-anisaldehyde

Downstream raw materials:

[4-(2-Methoxy-phenyl)-2-oxo-oxazolidin-3-yl]-acetic acid

[4-(2-Methoxy-phenyl)-2-oxo-oxazolidin-3-yl]-acetic acid ethyl ester