di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate)

Base Information

• Chemical Name: di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate)
• CAS No.: 1597416-75-5
• Molecular Formula: C₈₀H₁₁₂N₁₀O₁₈
• Molecular Weight: 1501.83
• Mol file: 1597416-75-5.mol

Synonyms:di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate)

Chemical Property of di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate)

There total 1 articles about di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-(((benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanamido)benzoic acid) (1597416-72-2) + tert-butyl (S)-(5-amino-6-(isobutylamino)-6-oxohexyl)carbamate (1597416-74-4) → di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate) (1597416-75-5)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -10 - 60 ℃; for 16.25h; Inert atmosphere;

DOI:10.1002/anie.201309353

Reference yield: 75.0%

di-tert-butyl 5,5'-((ethyne-1,2-diylbis(3-(((S)-6-((tert-butoxycarbonyl)amino)-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))(4S,4'S)-bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoate) (1597416-75-5) + trifluoroacetic acid (76-05-1) → (4S,4'S)-5,5'-(((S)-ethyne-1,2-diylbis(3-(((S)-6-amino-1-(isobutylamino)-1-oxohexan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(4-(((benzyloxy)carbonyl)amino)-5-oxopentanoic acid) bis-trifluoroacetic acid

Guidance literature:

In dichloromethane; for 1h; Inert atmosphere;

DOI:10.1002/anie.201309353

upstream raw materials:

2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-(((benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanamido)benzoic acid)

tert-butyl (S)-(5-amino-6-(isobutylamino)-6-oxohexyl)carbamate