4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline

Base Information

Chemical Name:4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline
CAS No.:1454833-81-8
Molecular Formula:C₂₇H₃₅ClN₆O₃
Molecular Weight:527.066
Hs Code.:

Synonyms:4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline

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Chemical Property of 4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline

Chemical Property:

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Technology Process of 4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline

There total 10 articles about 4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

: 1454833-85-2
4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-aminoquinazoline

: 543-27-1
isobutyl chloroformate

: 1454833-81-8
4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline

Guidance literature:: With pyridine; In tetrahydrofuran; at -10 ℃; for 12h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

: 2-dipropylamino-N-(2-chloro-4-nitrophenyl)acetamide

: 1454833-81-8
4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: iron; hydrogenchloride / ethanol; water / 4 h / 20 °C / Reflux

2: triethylamine / isopropyl alcohol / 8 h / Reflux

3: iron; hydrogenchloride / ethanol; water / 4 h / 20 °C / Reflux

4: dmap / chloroform / 20 h / 0 - 20 °C

With hydrogenchloride; dmap; iron; triethylamine; In ethanol; chloroform; water; isopropyl alcohol;
DOI:10.1002/cmdc.201300120

Reference yield:

: 1454833-84-1
4-(3-chloro-4-(2-(dipropylamino)acetamido)anilino)-6-nitroquinazoline

: 1454833-81-8
4-[3-chloro-4-(2-dipropylaminoacetylamino)anilino]-6-isobutoxycarboxamidoquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: iron; hydrogenchloride / ethanol; water / 4 h / 20 °C / Reflux

2: dmap / chloroform / 20 h / 0 - 20 °C

With hydrogenchloride; dmap; iron; In ethanol; chloroform; water;
DOI:10.1002/cmdc.201300120