17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate

Base Information

• Chemical Name: 17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate
• CAS No.: 104008-76-6
• Molecular Formula: C₂₈H₃₀O₆
• Molecular Weight: 462.543
• Mol file: 104008-76-6.mol

Synonyms:17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate

Chemical Property of 17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate

There total 3 articles about 17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

17α-benzoyloxy-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione (31311-74-7) → 17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate (104008-76-6)

Guidance literature:

With air; copper diacetate; In methanol; for 0.5h;

DOI:10.1002/jps.2600740215

Reference yield:

prednisolon (50-24-8,8056-11-9) → 17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate (104008-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridinium p-toluenesulfonate / dioxane / 10 h / Heating

2: 80 percent / cupric acetate, air / methanol / 0.5 h

With air; copper diacetate; pyridinium p-toluenesulfonate; In 1,4-dioxane; methanol;

DOI:10.1002/jps.2600740215

Reference yield:

orthobenzoic acid trimethyl ester (707-07-3) → 17α-benzoyloxy-11β,21,21-trihydroxy-1,4-pregnadien-3-one hydrate (104008-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridinium p-toluenesulfonate / dioxane / 10 h / Heating

2: 80 percent / cupric acetate, air / methanol / 0.5 h

With air; copper diacetate; pyridinium p-toluenesulfonate; In 1,4-dioxane; methanol;

DOI:10.1002/jps.2600740215

upstream raw materials:

17α-benzoyloxy-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione

prednisolon

orthobenzoic acid trimethyl ester

Downstream raw materials:

(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione